Drug Delivery: Surfactant‐Stripped Cabazitaxel Micelles Stabilized by Clotrimazole or Mifepristone (Adv. Therap. 3/2020)
نویسندگان
چکیده
منابع مشابه
Imaging the delivery of drug-loaded, iron-stabilized micelles.
Nanoparticle drug carriers hold potential to improve current cancer therapy by delivering payload to the tumor environment and decreasing toxic side effects. Challenges in nanotechnology drug delivery include plasma instability, site-specific delivery, and relevant biomarkers. We have developed a triblock polymer comprising a hydroxamic acid functionalized center block that chelates iron to for...
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Despite being one of the most promising amphiphilic block copolymers, use of Pluronic F68 in drug delivery is limited due to its high critical micelle concentration (CMC). In this study, we developed a novel F68 derivative, cholesterol-coupled F68 (F68-CHMC). This new derivative has a CMC of 10 μg/mL, which is 400-fold lower than that of F68. The drug-loading capacity of F68-CHMC was investigat...
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Polymer micelles have been used widely in the delivery of various therapeutic drugs, which are also known as active pharmaceutical ingredients (APIs). Recent advances in drug discovery technology, including an accumulated database on therapeutic targets, combinational chemistry, and high-throughput screening (HTS), have further increased the number of candidate compounds and constructed a huge ...
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ژورنال
عنوان ژورنال: Advanced Therapeutics
سال: 2020
ISSN: 2366-3987,2366-3987
DOI: 10.1002/adtp.202070007